Spectroscopic Studies of Copper and Silver Binding to Metallothioneins
نویسندگان
چکیده
منابع مشابه
Spectroscopic Studies of Copper and Silver Binding to Metallothioneins
MAMMALIAN METALLOTHIONEIN IS REMARKABLE IN ITS METAL BINDING PROPERTIES: well-characterized species exist for metal to sulfur ratios of M(7)S(20), M(12)S(20), and M(18)S(20), where M = Cd(ll), Zn(ll), Hg(ll), Ag(I), Au(I), and Cu(I). Circular dichroism and luminescence spectra provide rich details of a complicated metal binding chemistry when metals are added directly to the metal free- or zinc...
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Metallothionein is a ubiquitous protein with a wide range of proposed physiological roles, including the transport, storage and detoxification of essential and nonessential trace metals. The amino acid sequence of isoform 2a of rabbit liver metallothionein, the isoform used in our spectroscopic studies, includes 20 cysteinyl groups out of 62 amino acids. Metallothioneins in general represent an...
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ژورنال
عنوان ژورنال: Metal-Based Drugs
سال: 1999
ISSN: 0793-0291
DOI: 10.1155/mbd.1999.277